Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection.

ABSTRACT:

Background

Neuro-cognitive impairment is a deleterious complication of bacterial infections that is difficult to treat or prevent. Listeria monocytogenes (Lm) is a neuroinvasive bacterial pathogen and commonly used model organism for studying immune responses to infection. Antibiotic-treated mice that survive systemic Lm infection have increased numbers of CD8⁺ and CD4⁺ T-lymphocytes in the brain that include tissue resident memory (T_RM) T cells, but post-infectious cognitive decline has not been demonstrated. We hypothesized that Lm infection would trigger cognitive decline in accord with increased numbers of recruited leukocytes.

Methods

Male C57BL/6J mice (age 8 wks) were injected with neuroinvasive Lm 10

SUBMITTER: Cassidy BR 

PROVIDER: S-EPMC10151798 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature