Identification of bicalutamide resistance-related genes and prognosis prediction in patients with prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) is the second most common type of cancer and the fifth leading cause of cancer-related death in men. Androgen deprivation therapy (ADT) has become the first-line therapy for inhibiting PCa progression; however, nearly all patients receiving ADT eventually progress to castrate-resistant prostate cancer. Therefore, this study aimed to identify hub genes related to bicalutamide resistance in PCa and provide new insights into endocrine therapy resistance.

Methods

The data were obtained from public databases. Weighted correlation network analysis was used to identify the gene modules related to bicalutamide resistance, and the relationship between the samples and disease-free survival was analyzed. Gene Ontology and Kyoto Encyclopedia of Genes and

SUBMITTER: Li Y 

PROVIDER: S-EPMC10151815 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature