Effects of discontinuation of levothyroxine treatment in older adults: protocol for a self-controlled trial.

ABSTRACT:

Background

Many older persons use the thyroid hormone levothyroxine which is often continued for life. Scientifically, there is much uncertainty whether simple continuation is the optimal approach. First, the physical need for levothyroxine can decrease with age thereby posing a higher risk of overtreatment and adverse effects. Second, large trials in subclinical hypothyroidism have shown no benefit for the use of levothyroxine. Interestingly, guidelines do not address re-evaluation of the indication. This self-controlled trial aims to determine the effects of discontinuation of levothyroxine treatment in older adults.

Methods and analysis

Participants are community-dwelling subjects aged ≥60 years using levothyroxine continuously at a stable dosage of ≤150 µg and a level of

SUBMITTER: Ravensberg AJ 

PROVIDER: S-EPMC10151847 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature