Association between minimal decrease in platelet counts and outcomes in septic patients: a retrospective observational study.

ABSTRACT:

Objectives

Although platelets have been linked to inflammatory development in sepsis, knowledge on their role as an indicator in sepsis treatment is scarce. Here, we investigated the association between time-dependent changes in platelet counts with mortality rates to reveal the role of platelets in sepsis therapy.

Design

A retrospective cohort study.

Setting

We screened the Medical Information Mart for Intensive Care (MIMIC-IV), a public database comprising data from critical care subjects at the Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts, USA.

Participants

A total of 7981 patients, who were admitted to the BIDMC between 2008 and 2019, were analysed based on Sepsis-3 criteria from MIMIC-IV.

Primary and secondary outcome measures</

SUBMITTER: Liu X 

PROVIDER: S-EPMC10151909 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature