Association of trajectories of non-high-density lipoprotein cholesterol concentration with risk of cardiovascular disease: the Kailuan Study.

ABSTRACT:

Objectives

This study aimed to assess the association between longitudinal change in non-high-density lipoprotein cholesterol (non-HDL-C) and subsequent cardiovascular disease (CVD) risk.

Design

A retrospective study.

Setting

Data were obtained from the Kailuan Study, a dynamic cohort study initiated in 2006 in Tangshan, China.

Participants

The current study included 41 085 participants (mean age 53.9±11.6 years) free of CVD events in or before 2012. The non-HDL-C trajectory was developed according to the repeated measurement during 2006-2012 surveys to predict the CVD risk from 2012 to 2020.

Primary outcome measures

CVD events included myocardial infarction and stroke.

Results

3 discrete non-HDL-C trajectories were identified: low-increasing (n=2

SUBMITTER: Ding X 

PROVIDER: S-EPMC10151948 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature