A stable sensory map emerges from a dynamic equilibrium of neurons with unstable tuning properties.

ABSTRACT: Recent long-term measurements of neuronal activity have revealed that, despite stability in large-scale topographic maps, the tuning properties of individual cortical neurons can undergo substantial reformatting over days. To shed light on this apparent contradiction, we captured the sound response dynamics of auditory cortical neurons using repeated 2-photon calcium imaging in awake mice. We measured sound-evoked responses to a set of pure tone and complex sound stimuli in more than 20,000 auditory cortex neurons over several days. We found that a substantial fraction of neurons dropped in and out of the population response. We modeled these dynamics as a simple discrete-time Markov chain, capturing the continuous changes in responsiveness observed during stable behavioral and environment

SUBMITTER: Chambers AR 

PROVIDER: S-EPMC10152095 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature