Development of neonatal brain functional centrality and alterations associated with preterm birth.

ABSTRACT: Formation of the functional connectome in early life underpins future learning and behavior. However, our understanding of how the functional organization of brain regions into interconnected hubs (centrality) matures in the early postnatal period is limited, especially in response to factors associated with adverse neurodevelopmental outcomes such as preterm birth. We characterized voxel-wise functional centrality (weighted degree) in 366 neonates from the Developing Human Connectome Project. We tested the hypothesis that functional centrality matures with age at scan in term-born babies and is disrupted by preterm birth. Finally, we asked whether neonatal functional centrality predicts general neurodevelopmental outcomes at 18 months. We report an age-related increase in functional centr

SUBMITTER: Fenn-Moltu S 

PROVIDER: S-EPMC10152096 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature