Fetal development of functional thalamocortical and cortico-cortical connectivity.

ABSTRACT: Measuring and understanding functional fetal brain development in utero is critical for the study of the developmental foundations of our cognitive abilities, possible early detection of disorders, and their prevention. Thalamocortical connections are an intricate component of shaping the cortical layout, but so far, only ex-vivo studies provide evidence of how axons enter the sub-plate and cortex during this highly dynamic phase. Evidence for normal in-utero development of the functional thalamocortical connectome in humans is missing. Here, we modeled fetal functional thalamocortical connectome development using in-utero functional magnetic resonance imaging in fetuses observed from 19th to 40th weeks of gestation (GW). We observed a peak increase of thalamocortical functional connectivi

SUBMITTER: Taymourtash A 

PROVIDER: S-EPMC10152101 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature