Ten Years of Extracellular Matrix Proteomics: Accomplishments, Challenges, and Future Perspectives.

ABSTRACT: The extracellular matrix (ECM) is a complex assembly of hundreds of proteins forming the architectural scaffold of multicellular organisms. In addition to its structural role, the ECM conveys signals orchestrating cellular phenotypes. Alterations of ECM composition, abundance, structure, or mechanics have been linked to diseases and disorders affecting all physiological systems, including fibrosis and cancer. Deciphering the protein composition of the ECM and how it changes in pathophysiological contexts is thus the first step toward understanding the roles of the ECM in health and disease and toward the development of therapeutic strategies to correct disease-causing ECM alterations. Potentially, the ECM also represents a vast, yet untapped reservoir of disease biomarkers. ECM proteins ar

SUBMITTER: Naba A 

PROVIDER: S-EPMC10152135 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature