Atrial Fibrillation Incidence Associated With Exposure to Anticancer Drugs Used as Monotherapy in Clinical Trials.

ABSTRACT:

Background

The incidence of atrial fibrillation (AF) associated with anticancer drugs in cancer patients remains incompletely defined.

Objectives

The primary outcome was the annualized incidence rate of AF reporting associated with exposure to 1 of 19 anticancer drugs used as monotherapy in clinical trials. The authors also report the annualized incidence rate of AF reported in the placebo arms of these trials.

Methods

The authors systematically searched ClinicalTrials.gov for phase 2 and 3 cancer trials studying 19 different anticancer drugs of interest used as monotherapy, up to September 18, 2020. The authors performed a random-effects meta-analysis to compute summary AF annualized incidence rate with its 95% CI using log transformation and inverse variance weighti

SUBMITTER: Alexandre J 

PROVIDER: S-EPMC10152197 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature