Tumor Genomic Profile Is Associated With Arterial Thromboembolism Risk in Patients With Solid Cancer.

ABSTRACT:

Background

Patients with cancer have an increased risk for arterial thromboembolism (ATE). Scant data exist about the impact of cancer-specific genomic alterations on the risk for ATE.

Objectives

The aim of this study was to determine whether individual solid tumor somatic genomic alterations influence the incidence of ATE.

Methods

A retrospective cohort study was conducted using tumor genetic alteration data from adults with solid cancers who underwent Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets testing between 2014 and 2016. The primary outcome, ATE, was defined as myocardial infarction, coronary revascularization, ischemic stroke, peripheral arterial occlusion, or limb revascularization and identified through systematic elect

SUBMITTER: Feldman S 

PROVIDER: S-EPMC10152200 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature