Personalized monitoring of ambulatory function with a smartphone 2-minute walk test in multiple sclerosis.

ABSTRACT:

Background

Remote smartphone-based 2-minute walking tests (s2MWTs) allow frequent and potentially sensitive measurements of ambulatory function.

Objective

To investigate the s2MWT on assessment of, and responsiveness to change in ambulatory function in MS.

Methods

One hundred two multiple sclerosis (MS) patients and 24 healthy controls (HCs) performed weekly s2MWTs on self-owned smartphones for 12 and 3 months, respectively. The timed 25-foot walk test (T25FW) and Expanded Disability Status Scale (EDSS) were assessed at 3-month intervals. Anchor-based (using T25FW and EDSS) and distribution-based (curve fitting) methods were used to assess responsiveness of the s2MWT. A local linear trend model was used to fit weekly s2MWT scores of individual patients.

Results

SUBMITTER: Lam KH 

PROVIDER: S-EPMC10152211 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature