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Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma.


ABSTRACT:

Significance

Comprehensive profiling of the enhancer landscape and 3D genome structure in liposarcoma identifies extensive enhancer-oncogene coamplification and enhancer hijacking events, deepening the understanding of how oncogenes are regulated in cancer.

SUBMITTER: Liu T 

PROVIDER: S-EPMC10152236 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Publications

Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma.

Liu Tingting T   Wang Juan J   Yang Hongbo H   Jin Qiushi Q   Wang Xiaotao X   Fu Yihao Y   Luan Yu Y   Wang Qixuan Q   Youngblood Mark W MW   Lu Xinyan X   Casadei Lucia L   Pollock Raphael R   Yue Feng F  

Cancer research 20230501 9


<h4>Significance</h4>Comprehensive profiling of the enhancer landscape and 3D genome structure in liposarcoma identifies extensive enhancer-oncogene coamplification and enhancer hijacking events, deepening the understanding of how oncogenes are regulated in cancer. ...[more]

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