Profiling of serum oxylipins identifies distinct spectrums and potential biomarkers in young people with very early onset gout.

ABSTRACT:

Objective

Oxylipins modulate inflammation via complex pathways. The oxylipin profile in gout remains unexplored. In this study, we systemically profiled oxylipins in young men and identified new oxylipin biomarkers for clinical use in differentiating gout from hyperuricaemia.

Material and methods

Oxylipin profiling was performed in 90 men (30 very early onset gout, 30 asymptomatic hyperuricaemia [HU] and 30 normouricaemia [NU], all aged <20 years) divided into discovery and validation sample sets. The dataset was analysed based on orthogonal projection to latent structure-discriminant analysis. Correlation network and pathway enrichment were conducted to reveal potential oxylipin-involved pathways of gout. Candidate oxylipins were further evaluated and optimized in the valid

SUBMITTER: Wang C 

PROVIDER: S-EPMC10152281 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature