Association of mycophenolate and azathioprine use with cognitive function in systemic lupus.

ABSTRACT:

Objectives

Cognitive dysfunction (CD) is a common manifestation of SLE that can have detrimental consequences for those affected. To date, no treatments have been approved for SLE-CD. This study aims to assess the association of azathioprine (AZA) and mycophenolate (MMF) use with SLE-CD, given that these medications have demonstrated neuroprotective qualities in prior studies.

Methods

Consecutive adult SLE patients presenting to a single healthcare center were considered for participation. The ACR neuropsychological battery for SLE was administered to consenting patients at 0, 6 and 12 months. Scores were compared with age- and sex-matched controls. Primary outcome was CD, defined as a z-score ≤-1.5 in two or more cognitive domains. Mixed-effects logistic regression models w

SUBMITTER: Dobrowolski C 

PROVIDER: S-EPMC10152298 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature