Heterogeneous plaque-lumen geometry is associated with major adverse cardiovascular events.

ABSTRACT:

Aims

Prospective studies show that only a minority of plaques with higher risk features develop future major adverse cardiovascular events (MACE), indicating the need for more predictive markers. Biomechanical estimates such as plaque structural stress (PSS) improve risk prediction but require expert analysis. In contrast, complex and asymmetric coronary geometry is associated with both unstable presentation and high PSS, and can be estimated quickly from imaging. We examined whether plaque-lumen geometric heterogeneity evaluated from intravascular ultrasound affects MACE and incorporating geometric parameters enhances plaque risk stratification.

Methods and results

We examined plaque-lumen curvature, irregularity, lumen aspect ratio (LAR), roughness, PSS, and their heteroge

SUBMITTER: Gu SZ 

PROVIDER: S-EPMC10152392 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature