Adipokines and incident venous thromboembolism: The Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background

Obesity leads to adipocyte hypertrophy and adipokine dysregulation and is an independent risk factor for venous thromboembolism (VTE). However, the association between adipokines and VTE is not well established.

Objectives

To examine whether adipokines are associated with increased risk of incident VTE.

Methods

We studied 1888 participants of the Multi-Ethnic Study of Atherosclerosis cohort who were initially free of VTE and had adipokine (adiponectin, leptin, and resistin) levels measured at either examination 2 or 3 (2002-2004 or 2004-2005, respectively). During follow-ups, VTE was ascertained through hospitalization records and death certificates by using ICD-9 and 10 codes. We used multivariable Cox proportional hazards regression to assess the associat

SUBMITTER: Broni EK 

PROVIDER: S-EPMC10152466 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature