Applying Na/Co(II) bimetallic partnerships to promote multiple Co-H exchanges in polyfluoroarenes.

ABSTRACT: Heterobimetallic base NaCo(HMDS)₃ [HMDS = N(SiMe₃)₂] enables regioselective di-cobaltation of activated polyfluoroarenes under mild reaction conditions. For 1,3,5-C₆H₂X₃ (X= Cl, F), NaCo(HMDS)₃ in excess at 80 °C impressively induces the collective cleavage of five bonds (two C-H and three C-X) of the substrates via a cascade activation process that cannot be replicated by LiCo(HMDS)₃ or KCo(HMDS)₃.

SUBMITTER: Logallo A 

PROVIDER: S-EPMC10152514 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature