Development of Rat Caries-Induced Pulpitis Model for Vital Pulp Therapy.

ABSTRACT: Rodent animal models for vital pulp therapy are commonly used in dental research because their tooth anatomy and cellular processes are similar to the anatomy and processes in humans. However, most studies have been conducted using uninfected sound teeth, which makes it difficult to adequately assess the inflammatory shift after vital pulp therapy. In the present study, we aimed to establish a caries-induced pulpitis model based on the conventional rat caries model and then evaluate inflammatory changes during the wound-healing process after pulp capping in a model of reversible pulpitis induced by carious infection. To establish the caries-induced pulpitis model, the pulpal inflammatory status was investigated at different stages of caries progression by immunostaining targeted to specifi

SUBMITTER: Huang H 

PROVIDER: S-EPMC10152557 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature