Cerebrospinal fluid-related tissue damage in multiple sclerosis patients with iron rim lesions.

ABSTRACT:

Background

In multiple sclerosis (MS), iron rim lesions (IRLs) are associated with pronounced tissue damage, higher disease severity and have been suggested as an imaging marker of chronic active inflammation behind the blood-brain barrier indicating progression. Furthermore, chronic intrathecal compartmentalized inflammation has been suggested to be a mediator of a cerebrospinal fluid (CSF)-related tissue damage.

Objective

To investigate CSF markers of intrathecal inflammation in patients with at least one IRL compared to patients without IRLs and to investigate tissue damage in lesions and normal-appearing white matter (NAWM) with proximity to CSF spaces.

Methods

A total of 102 patients (51 with at least 1 IRL and 51 age-/sex-matched patients without IRL) scanned wi

SUBMITTER: Wittayer M 

PROVIDER: S-EPMC10152561 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature