Cutaneous lesions in psoriatic arthritis are enriched in chemokine transcriptomic pathways.

ABSTRACT:

Objectives

Skin from people with psoriasis has been extensively studied and is assumed to be identical to skin from those with psoriatic arthritis (PsA). Chemokines and the CC chemokine scavenger receptor ACKR2 are upregulated in uninvolved psoriasis. ACKR2 has been proposed as a regulator of cutaneous inflammation in psoriasis. The aim of this study was to compare the transcriptome of PsA skin to healthy control (HC) skin and evaluate ACKR2 expression in PsA skin.

Methods

Full-thickness skin biopsies from HC, lesional and uninvolved skin from participants with PsA were sequenced on NovaSeq 6000. Findings were validated using qPCR and RNAscope.

Results

Nine HC and nine paired PsA skin samples were sequenced. PsA uninvolved skin was transcriptionally similar to HC skin

SUBMITTER: Johnsson H 

PROVIDER: S-EPMC10152590 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature