Peripheral blood lymphocytes influence human papillomavirus infection and clearance: a retrospective cohort study.

ABSTRACT:

Background

There is a close correlation between HPV infection and systemic immune status. The purpose of this study was to determine which lymphocytes in peripheral blood influence human papillomavirus (HPV) infection and to identify whether peripheral blood lymphocyte (PBL) subsets could be used as biomarkers to predict HPV clearance in the short term.

Methods

This study involved 716 women undergoing colposcopy from 2019 to 2021. Logistic and Cox regression were used to analyze the association of PBLs with HPV infection and clearance. Using Cox regression, bidirectional stepwise regression and the Akaike information criterion (AIC), lymphocyte prediction models were developed, with the C-index assessing performance. ROC analysis determined optimal cutoff values, and their a

SUBMITTER: Li Y 

PROVIDER: S-EPMC10152704 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature