Amino acid metabolism regulated by lncRNAs: the propellant behind cancer metabolic reprogramming.

ABSTRACT: Metabolic reprogramming is one of the main characteristics of cancer cells and plays pivotal role in the proliferation and survival of cancer cells. Amino acid is one of the key nutrients for cancer cells and many studies have focused on the regulation of amino acid metabolism, including the genetic alteration, epigenetic modification, transcription, translation and post-translational modification of key enzymes in amino acid metabolism. Long non-coding RNAs (lncRNAs) are composed of a heterogeneous group of RNAs with transcripts of more than 200 nucleotides in length. LncRNAs can bind to biological molecules such as DNA, RNA and protein, regulating the transcription, translation and post-translational modification of target genes. Now, the functions of lncRNAs in cancer metabolism have ar

SUBMITTER: Hu Q 

PROVIDER: S-EPMC10152737 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature