Candidate genes identification and RNA-seq based pathway analysis associated with primary angle-closure glaucoma with cataract.

ABSTRACT:

Background

Cataract is commonly observed in patients with primary angle-closure glaucoma; however, its underlying pathological mechanisms remain unclear. This study aimed to improve our knowledge on the pathological processes involved in primary angle-closure glaucoma (PACG) by identifying potential prognostic genes associated with cataract progression.

Methods

Thirty anterior capsular membrane samples were collected from PACG patients with cataracts and age-related cataracts. Differentially expressed genes (DEGs) between these two cohorts were analyzed using high-throughput sequencing. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to screen the DEGs, and potential prognostic markers and their coexpression network were then predicted by bi

SUBMITTER: Liu M 

PROVIDER: S-EPMC10152770 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature