Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth.

ABSTRACT:

Background

Inflammation-related predisposition to cancer plays an essential role in cancer progression and is associated with poor prognosis. A hypoxic microenvironment and neutrophil infiltration are commonly present in solid tumours, including gastric cancer (GC). Neutrophil extracellular traps (NETs) have also been demonstrated in the tumour immune microenvironment (TIME), but how NETs affect GC progression remains unknown. Here, we investigated the role of NET formation in the TIME and further explored the underlying mechanism of NETs in GC tumour growth.

Methods

Hypoxia-induced factor-1α (HIF-1α), citrulline histone 3 (citH3) and CD66b expression in tumour and adjacent nontumor tissue samples was evaluated by western blotting, immunofluorescence and immunohistochemical

SUBMITTER: Li J 

PROVIDER: S-EPMC10152773 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature