Parasagittal dural space hypertrophy and amyloid-β deposition in Alzheimer's disease.

ABSTRACT: One of the pathological hallmarks of Alzheimer's and related diseases is the increased accumulation of protein amyloid-β in the brain parenchyma. As such, recent studies have focused on characterizing protein and related clearance pathways involving perivascular flow of neurofluids, but human studies of these pathways are limited owing to limited methods for evaluating neurofluid circulation non-invasively in vivo. Here, we utilize non-invasive MRI methods to explore surrogate measures of CSF production, bulk flow and egress in the context of independent PET measures of amyloid-β accumulation in older adults. Participants (N = 23) were scanned at 3.0 T with 3D T₂-weighted turbo spin echo, 2D perfusion-weighted pseudo-continuous arterial spin labelling and phase-con

SUBMITTER: Song AK 

PROVIDER: S-EPMC10152899 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature