Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts.

ABSTRACT:

Background

Oral health is a key indicator of overall health, well-being, and quality of life. Several studies have provided new evidence about the role of oral diseases, specifically periodontitis, in generating risk for various forms of cancers, including lung, colorectal, and pancreatic cancers.

Methods

Incident lung cancer cases (n = 192) and matched controls (n = 192) were selected from participants of the CLUE I and CLUE II cohorts. Archived serum samples collected from participants in 1974 (in CLUE I) were analyzed using immunoblotting for immunoglobulin G (IgG) antibody levels to 13 bacteria of the periodontium. Associations between antibody levels and lung cancer were estimated using conditional logistic regression.

Results

Most of the periodontal bacterial an

SUBMITTER: Ampomah NK 

PROVIDER: S-EPMC10152995 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature