Chelating silica nanoparticles for efficient antibiotic delivery and particle imaging in Gram-negative bacteria.

ABSTRACT: The inefficacy of antibiotics against Gram-negative bacteria is a major challenge for treatment of many clinically important bacterial infections. The complex structure of the double cell membrane of Gram-negative bacteria makes it inaccessible to many key antibiotics such as vancomycin and also presents a major challenge for drug development. In this study we design of a novel hybrid silica nanoparticle system bearing membrane targeting groups with the antibiotic encapsulated together with a ruthenium luminescent tracking agent, for optical detection of the nanoparticle delivery in the bacterial cell. The hybrid system shows delivery of vancomycin and efficacy against a library of Gram negative bacterial species. Evidence of penetration of nanoparticles in bacteria cells is achieved vi

SUBMITTER: Muguruza AR 

PROVIDER: S-EPMC10153079 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature