Netrin-1 directs vascular patterning and maturity in the developing kidney.

ABSTRACT: Blood filtering by the kidney requires the establishment of an intricate vascular system that works to support body fluid and organ homeostasis. Despite these critical roles, little is known about how vascular architecture is established during kidney development. More specifically, how signals from the kidney influence vessel maturity and patterning remains poorly understood. Netrin-1 (Ntn1) is a secreted ligand critical for vessel and neuronal guidance. Here, we demonstrate that Ntn1 is expressed by stromal progenitors in the developing kidney, and conditional deletion of Ntn1 from Foxd1+ stromal progenitors (Foxd1^GC/+;Ntn1^fl/fl) results in hypoplastic kidneys that display extended nephrogenesis. Despite expression of

SUBMITTER: Honeycutt SE 

PROVIDER: S-EPMC10153117 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature