Quantitative mechanistic model reveals key determinants of placental IgG transfer and informs prenatal immunization strategies.

ABSTRACT: Transplacental antibody transfer is crucially important in shaping neonatal immunity. Recently, prenatal maternal immunization has been employed to boost pathogen-specific immunoglobulin G (IgG) transfer to the fetus. Multiple factors have been implicated in antibody transfer, but how these key dynamic regulators work together to elicit the observed selectivity is pertinent to engineering vaccines for mothers to optimally immunize their newborns. Here, we present the first quantitative mechanistic model to uncover the determinants of placental antibody transfer and inform personalized immunization approaches. We identified placental FcγRIIb expressed by endothelial cells as a limiting factor in receptor-mediated transfer, which plays a key role in promoting preferential transport of subcla

SUBMITTER: Erdogan RR 

PROVIDER: S-EPMC10153162 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature