Imaging-based screening identifies modulators of the eIF3 translation initiation factor complex in Candida albicans.

ABSTRACT: Fungal pathogens like Candida albicans can cause devastating human disease. Treatment of candidemia is complicated by the high rate of resistance to common antifungal therapies. Additionally, there is host toxicity associated with many antifungal compounds due to the conservation between essential mammalian and fungal proteins. An attractive new approach for antimicrobial development is to target virulence factors: non-essential processes that are required for the organism to cause disease in human hosts. This approach expands the potential target space while reducing the selective pressure towards resistance, as these targets are not essential for viability. In C. albicans, a key virulence factor is the ability to transition to hyphal morphology. We developed a high-throughp

SUBMITTER: Metzner K 

PROVIDER: S-EPMC10153179 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature