Phenotype control techniques for Boolean gene regulatory networks.

ABSTRACT: Modeling cell signal transduction pathways via Boolean networks (BNs) has become an established method for analyzing intracellular communications over the last few decades. What’s more, BNs provide a course-grained approach, not only to understanding molecular communications, but also for targeting pathway components that alter the long-term outcomes of the system. This has come to be known as phenotype control theory . In this review we study the interplay of various approaches for controlling gene regulatory networks such as: algebraic methods, control kernel, feedback vertex set, and stable motifs. The study will also include comparative discussion between the methods, using an established cancer model of T-Cell Large Granular Lymphocyte (T-LGL) Leukemia. Further, we explore po

SUBMITTER: Plaugher D 

PROVIDER: S-EPMC10153207 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature