Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test.

ABSTRACT: Drug exposure during adolescence, when the 'reward' circuitry of the brain is developing, can permanently impact reward-related behavior. Epidemiological studies show that opioid treatment during adolescence, such as pain management for a dental procedure or surgery, increases the incidence of psychiatric illness including substance use disorders. Moreover, the opioid epidemic currently in the United States is affecting younger individuals raising the impetus to understand the pathogenesis of the negative effects of opioids. One reward-related behavior that develops during adolescence is social behavior. We previously demonstrated that social development occurs in rats during sex-specific adolescent periods: early to mid-adolescence in males (postnatal day (P)30-40) and pre-early adolescen

SUBMITTER: King'uyu DN 

PROVIDER: S-EPMC10153224 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature