The ATP-exporting channel Pannexin-1 promotes CD8⁺ T cell effector and memory responses.

ABSTRACT: Sensing of extracellular ATP (eATP) controls CD8⁺ T cell function. Their accumulation can occur through export by specialized molecules, such as the release channel Pannexin-1 (Panx1). Whether Panx1 controls CD8⁺ T cell immune responses in vivo, however, has not been previously addressed. Here, we report that T cell-specific Panx1 is needed for CD8⁺ T cell responses to viral infections and cancer. We found that CD8-specific Panx1 promotes both effector and memory CD8⁺ T cell responses. Panx1 favors initial effector CD8⁺ T cell activation through extracellular ATP (eATP) export and subsequent P2RX4 activation, which helps promote full effector differentiation through extracellular lactate accumulation and its subsequent recycling

SUBMITTER: Vardam-Kaur T 

PROVIDER: S-EPMC10153284 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature