Medial entorhinal cortex plays a specialized role in learning of flexible, context-dependent interval timing behavior.

ABSTRACT: In order to survive and adapt in a dynamic environment, animals must perceive and remember the temporal structure of events and actions across a wide range of timescales, including so-called interval timing on the scale of seconds to minutes^1,2. Episodic memory (i.e. the ability to remember specific, personal events that occur in spatial and temporal context) requires accurate temporal processing and is known to require neural circuits in the medial temporal lobe (MTL), including medial entorhinal cortex (MEC)^3-5. Recently, it has been discovered that neurons in MEC termed time cells, fire regularly at brief moments as animals engage in interval timing behavior, and as a population, display sequential neural activity that tiles the entire timed epoch⁶. It h

SUBMITTER: Bigus ER 

PROVIDER: S-EPMC10153298 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature