Dataset Information

Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct ( ² H) and indirect ( ¹ H) detection of deuterium labeled compounds at 7T and clinical 3T.

ABSTRACT:

Introduction

Deuterium metabolic imaging (DMI) and quantitative exchange label turnover (QELT) are novel MR spectroscopy techniques for non-invasive imaging of human brain glucose and neurotransmitter metabolism with high clinical potential. Following oral or intravenous administration of non-ionizing [6,6'- ² H ₂ ]-glucose, its uptake and synthesis of downstream metabolites can be mapped via direct or indirect detection of deuterium resonances using ² H MRSI (DMI) and ¹ H MRSI (QELT), respectively. The purpose of this study was to compare the dynamics of spatially resolved brain glucose metabolism, i.e., estimated concentration enrichment of deuterium labeled Glx (glutamate+glutamine) and Glc (glucose) acquired repeatedly in the same coh

SUBMITTER: Niess F

PROVIDER: S-EPMC10153308 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Dataset Information

Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct ( ² H) and indirect ( ¹ H) detection of deuterium labeled compounds at 7T and clinical 3T.

Introduction

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct ( 2 H) and indirect ( 1 H) detection of deuterium labeled compounds at 7T and clinical 3T.

Introduction

OmicsDI is part of the ELIXIR infrastructure

Tweets

Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct ( ² H) and indirect ( ¹ H) detection of deuterium labeled compounds at 7T and clinical 3T.