Sleep Regularity and Mortality: A Prospective Analysis in the UK Biobank.

ABSTRACT:

Background

Irregular sleep-wake timing may cause circadian disruption leading to several chronic age-related diseases. We examined the relationship between sleep regularity and risk of all-cause, cardiovascular disease (CVD), and cancer mortality in 88,975 participants from the prospective UK Biobank cohort.

Methods

The sleep regularity index (SRI) was calculated as the probability of an individual being in the same state (asleep or awake) at any two time points 24 hours apart, averaged over 7-days of accelerometry (range 0-100, with 100 being perfectly regular). The SRI was related to the risk of mortality in time-to-event models.

Findings

The mean sample age was 62 years (SD, 8), 56% were women, and the median SRI was 60 (SD, 10). There were 3010 deaths during a mea

SUBMITTER: Cribb L 

PROVIDER: S-EPMC10153326 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature