Thymosin β4 and prothymosin α promote cardiac regeneration post-ischaemic injury in mice.

ABSTRACT:

Aims

The adult mammalian heart is a post-mitotic organ. Even in response to necrotic injuries, where regeneration would be essential to reinstate cardiac structure and function, only a minor percentage of cardiomyocytes undergo cytokinesis. The gene programme that promotes cell division within this population of cardiomyocytes is not fully understood. In this study, we aimed to determine the gene expression profile of proliferating adult cardiomyocytes in the mammalian heart after myocardial ischaemia, to identify factors to can promote cardiac regeneration.

Methods and results

Here, we demonstrate increased 5-ethynyl-2'deoxyuridine incorporation in cardiomyocytes 3 days post-myocardial infarction in mice. By applying multi-colour lineage tracing, we show that this is parall

SUBMITTER: Gladka MM 

PROVIDER: S-EPMC10153422 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature