G Protein-Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications.

ABSTRACT: The actions of estrogens and related estrogenic molecules are complex and multifaceted in both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways that produce and respond to estrogens. Multiple receptors promulgate these responses, including the classical estrogen receptors of the nuclear hormone receptor family (estrogen receptors α and β), which function largely as ligand-activated transcription factors, and the 7-transmembrane G protein-coupled estrogen receptor, GPER, which activates a diverse array of signaling pathways. The pharmacology and functional roles of GPER in physiology and disease reveal important roles in responses to both natural and synthetic estrogenic compounds in numerous physiological systems. These functions have implications in the

SUBMITTER: Arterburn JB 

PROVIDER: S-EPMC10153636 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature