Dietary essential amino acids for the treatment of heart failure with reduced ejection fraction.

ABSTRACT:

Aims

Heart failure with reduced ejection fraction (HFrEF) is a leading cause of mortality worldwide, requiring novel therapeutic and lifestyle interventions. Metabolic alterations and energy production deficit are hallmarks and thereby promising therapeutic targets for this complex clinical syndrome. We aim to study the molecular mechanisms and effects on cardiac function in rodents with HFrEF of a designer diet in which free essential amino acids-in specifically designed percentages-substituted for protein.

Methods and results

Wild-type mice were subjected to transverse aortic constriction (TAC) to induce left ventricle (LV) pressure overload or sham surgery. Whole-body glucose homeostasis was studied with glucose tolerance test, while myocardial dysfunction and fibrosis we

SUBMITTER: Ragni M 

PROVIDER: S-EPMC10153641 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature