Association of viral kinetics, infection history, NS1 protein with plasma leakage among Indonesian dengue infected patients.

ABSTRACT:

Objectives

Plasma leakage, a hallmark of disease in Dengue virus (DENV) infection, is an important clinical manifestation and is often associated with numerous factors such as viral factors. The aim of this study is to investigate the association of virus serotype, viral load kinetics, history of infection, and NS1 protein with plasma leakage.

Methods

Subjects with fever ≤ 48 hours and positive DENV infection were included. Serial laboratory tests, viral load measurements, and ultrasonography examination to assess plasma leakage were performed.

Results

DENV-3 was the most common serotype found in the plasma leakage group (35%). Patients with plasma leakage demonstrated a trend of higher viral load and a longer duration of viremia compared to those without. This was si

SUBMITTER: Nainggolan L 

PROVIDER: S-EPMC10153689 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature