Spatial normalization discrepancies between native and MNI152 brain template scans in gamma ventral capsulotomy patients.

ABSTRACT: In neurosurgery, spatial normalization emerged as a tool to minimize inter-subject variability and study target point locations based on standard coordinates. The Montreal Neurological Institute's 152 brain template (MNI152) has become the most widely utilized in neuroimaging studies, but has been noted to introduce partial volume effects, distortions, and increase structure size in all directions (x/y/z axes). These discrepancies question the accuracy of the MNI template, as well as its utility for studies that examine and form conclusions from group-level data. Given that surgical precision in obsessive-compulsive disorder is essential to patient outcomes, we retrospectively investigated lesion size and location in patients (n = 21) who underwent capsulotomy for intractable OCD, comparin

SUBMITTER: Giff A 

PROVIDER: S-EPMC10153791 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature