Influence of glutathione-related genetic variants on the oxidative stress profile of Mexican patients with psychotic disorders.

ABSTRACT:

Objective

The clinical trajectories of patients with psychotic disorders have divergent outcomes, which may result in part from glutathione (GSH)-related high-risk genotypes. We aimed to determine pharmacokinetics of clozapine, GSH levels, GSH peroxidase (GPx) activity, gene variants involved in the synthesis and metabolism of GSH, and their association with psychotic disorders in Mexican patients on clozapine monotherapy and controls.

Methods

The sample included 75 patients with psychotic disorders on clozapine therapy and 40 paired healthy controls. Plasma clozapine/N-desmethylclozapine, GSH concentrations, and GPx activity were determined, along with genotyping of GCLC and GSTP1 variants and copy number variations of GSTP1, GSTT1, and GSTM1. Clinical, molecular and bioche

SUBMITTER: Mayen-Lobo YG 

PROVIDER: S-EPMC10154007 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature