Defining basic rules for hardening influenza A virus liquid condensates.

ABSTRACT: In biological systems, liquid and solid-like biomolecular condensates may contain the same molecules but their behaviour, including movement, elasticity, and viscosity, is different on account of distinct physicochemical properties. As such, it is known that phase transitions affect the function of biological condensates and that material properties can be tuned by several factors including temperature, concentration, and valency. It is, however, unclear if some factors are more efficient than others at regulating their behaviour. Viral infections are good systems to address this question as they form condensates de novo as part of their replication programmes. Here, we used influenza A virus (IAV) liquid cytosolic condensates, AKA viral inclusions, to provide a proof of concept that liqui

SUBMITTER: Etibor TA 

PROVIDER: S-EPMC10154025 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature