Pharmacogenetics of tenofovir clearance among Southern Africans living with HIV.

ABSTRACT:

Background

Tenofovir is a component of preferred combination antiretroviral therapy (ART) regimens in Africa. Few pharmacogenetic studies have been conducted on tenofovir exposure in Africa, where genetic diversity is greatest.

Objective

We characterized the pharmacogenetics of plasma tenofovir clearance in Southern Africans receiving tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide (TAF).

Methods

Adults randomized to TAF or TDF in dolutegravir-containing arms of the ADVANCE trial (NCT03122262) were studied. Linear regression models stratified by study arm examined associations with unexplained variability in tenofovir clearance. We investigated genetic associations with polymorphisms selected a priori followed by genome-wide associations.

Results

A

SUBMITTER: Cindi Z 

PROVIDER: S-EPMC10154044 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature