Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer's disease pathology.

ABSTRACT: The role of microglia in tau accumulation is currently unclear but could provide an important insight into the mechanisms underlying Alzheimer's disease (AD)¹. Here, we measured the microglial marker soluble TREM2 and the disease-associated microglial activation stage 2 markers AXL, MERTK, GAS6, LPL, CST7, SPP1 and CSF1 in nondemented individuals from the Swedish BioFINDER-2 cohort who underwent longitudinal tau-positron emission tomography (PET), amyloid-PET and global cognitive assessment. To assess whether baseline microglial markers had an effect on AD-related changes, we studied three sub-groups of individuals: 121 with evidence of amyloid-PET pathology (A⁺), 64 with additional evidence of tau-PET pathology (A⁺T⁺) and 159 without amyloid- or

SUBMITTER: Pereira JB 

PROVIDER: S-EPMC10154192 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature