Signs of immunosenescence correlate with poor outcome of mRNA COVID-19 vaccination in older adults.

ABSTRACT: Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is effective in preventing COVID-19 hospitalization and fatal outcome. However, several studies indicated that there is reduced vaccine effectiveness among older individuals, which is correlated with their general health status^1,2. How and to what extent age-related immunological defects are responsible for the suboptimal vaccine responses observed in older individuals receiving SARS-CoV-2 messenger RNA vaccine, is unclear and not fully investigated^1,3-5. In this observational study, we investigated adaptive immune responses in adults of various ages (22-99 years old) receiving 2 doses of the BNT162b2 mRNA vaccine. Vaccine-induced Spike-specific antibody, and T and memory B cell responses

SUBMITTER: Palacios-Pedrero MA 

PROVIDER: S-EPMC10154205 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature