Robust SARS-CoV-2-specific and heterologous immune responses in vaccine-naive residents of long-term care facilities who survive natural infection.

ABSTRACT: We studied humoral and cellular immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 152 long-term care facility staff and 124 residents over a prospective 4-month period shortly after the first wave of infection in England. We show that residents of long-term care facilities developed high and stable levels of antibodies against spike protein and receptor-binding domain. Nucleocapsid-specific responses were also elevated but waned over time. Antibodies showed stable and equivalent levels of functional inhibition against spike-angiotensin-converting enzyme 2 binding in all age groups with comparable activity against viral variants of concern. SARS-CoV-2 seropositive donors showed high levels of antibodies to other beta-coronaviruses but serostatus did not impact

SUBMITTER: Tut G 

PROVIDER: S-EPMC10154219 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature