Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes.

ABSTRACT: Third-dose coronavirus disease 2019 vaccines are being deployed widely but their efficacy has not been assessed adequately in vulnerable older people who exhibit suboptimal responses after primary vaccination series. This observational study, which was carried out by the VIVALDI study based in England, looked at spike-specific immune responses in 341 staff and residents in long-term care facilities who received an mRNA vaccine following dual primary series vaccination with BNT162b2 or ChAdOx1. Third-dose vaccination strongly increased antibody responses with preferential relative enhancement in older people and was required to elicit neutralization of Omicron. Cellular immune responses were also enhanced with strong cross-reactive recognition of Omicron. However, antibody titers fell 21-78

SUBMITTER: Tut G 

PROVIDER: S-EPMC10154221 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature