Long-term life history predicts current gut microbiome in a population-based cohort study.

ABSTRACT: Extensive scientific and clinical microbiome studies have explored contemporary variation and dynamics of the gut microbiome in human health and disease^1-3, yet the role of long-term life history effects has been underinvestigated. Here, we analyzed the current, quantitative microbiome composition in the older adult Bruneck Study cohort (Italians, Bruneck, n = 304 (male, 154; female, 150); age 65-98 years) with extensive clinical, demographic, lifestyle and nutritional data collected over the past 26 years⁴. Multivariate analysis of historical variables indicated that medication history, historical physical activity, past dietary habits and specific past laboratory blood parameters explain a significant fraction of current quantitative microbiome variation in older ad

SUBMITTER: Si J 

PROVIDER: S-EPMC10154234 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature